Hypoxemia During Extreme Hyperleukocytosis: How Spurious?

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چکیده

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Hypoxemia During Extreme Hyperleukocytosis: How Spurious?

BACKGROUND Spurious hypoxemia has been described in case reports during extreme hyperleukocytosis and has led to recommendations for immediate cooling and analysis of arterial blood gases (ABGs). We sought to determine, in samples processed as recommended, the magnitude of spurious hypoxemia in acute leukemia subjects with hyperleukocytosis. METHODS A retrospective chart review was conducted ...

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Spurious Hyperleukocytosis

Hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. Nucleated RBCs give rise to spuriously high total leucocyte count and cause clinical dilemma. Thalassemia major patients are known to have leucocytosis even after correction for nucleated RBCs. We report a case of undiagnosed Thalassemia major in a 4 month old infant with total leucocyte count highe...

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spurious hyperleukocytosis

hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. nucleated rbcs give rise to spuriously high total leucocyte count and cause clinical dilemma. thalassemia major patients are known to have leucocytosis even after correction for nucleated rbcs. we report a case of undiagnosed thalassemia major in a 4 month old infant with total leucocyte count highe...

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Blood oxygenation and spurious hypoxemia

In health pO2(a) is maintained within the range 10.613.3 kPa (80-100 mmHg) and hypoxemia (reduced blood oxygen) is diagnosed if pO2(a) is less than 10.6 kPa (80 mmHg). The purpose of this article is to highlight the spurious severe hypoxemia that occurs in patients with particularly high white-cell count or high platelet count. In these patients there is a marked discrepancy between measured (i...

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Unusual discrepancy between S(pO(2)) and S(aO(2)) in a 31-year-old man with chronic myelogenous leukemia.

Hyperleukocytosis and thrombocytosis may develop in hematological disorders, including acute myelogenous or lymphoblastic leukemia, chronic leukemias in accelerated phase, and polycythemia vera. In such clinical scenarios, patients are at risk for hypoxemia, either true or spurious.1 The causes of true hypoxemia may include pulmonary leukostasis, pneumonia, and pulmonary embolism.1 However, som...

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ژورنال

عنوان ژورنال: Respiratory Care

سال: 2015

ISSN: 0020-1324,1943-3654

DOI: 10.4187/respcare.04196